# A-12 — Bimatoprost

The largest, least ambiguous cosmetic result in this register — alongside two harms that do not reverse when you stop.

- **Canonical:** https://www.30plusskin.care/actives/bimatoprost
- **Site:** 30+/SKIN — Skincare, published as a spec sheet.
- **Issue:** ISSUE NO. 13 / REV. 2026.10
- **Standing terms:** INDEPENDENT · AFFILIATE-FUNDED · NOT MEDICAL ADVICE

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## Datasheet

- **INN / INCI:** Bimatoprost
- **Family:** Prostaglandin analogue
- **Molecular weight:** 415.57 g/mol
- **Layer reached:** EPIDERMIS
- **Prescription only:** yes
- **Evidence grade:** A
- **Controlled trials on file:** 1
- **Strength range recorded:** 0.03%–0.03%
- **Representative reference concentration:** 0.03%
- **Irritation (0–10):** 3
- **Onset:** 8–16 WK
- **Stability:** STERILE SOLUTION · SINGLE-USE APPLICATORS

## Mechanism

The concentration marker is not a recommended dose or a claim that other strengths are untested. Compare the vehicle, indication and trial population.

Extends the anagen growth phase of the eyelash follicle and increases the number of hairs in it. The same prostaglandin activity acts on melanocytes and on orbital adipose tissue, and cannot be dialled out.

## Measured endpoints

| Endpoint | Effect vs comparator | Window | Record |
| --- | --- | --- | --- |
| Global Eyelash Assessment, ≥1 grade | +60% | 16 WK | REF-22 — Latisse — pivotal eyelash hypotrichosis trial, week 16 (Multicentre randomised, vehicle-controlled, parallel, n=278, grade A) |

## Layering

- **Do not layer with:** Prostaglandin analogues for intraocular pressure, Active uveitis, Risk factors for macular edema
- **Pairs with:** Nothing — apply alone to the upper lid margin

## Notes

- Increased brown iris pigmentation may occur and the label says it is likely to be permanent.
- Postmarketing reports include periorbital fat atrophy producing a deepened eyelid sulcus and eyelid ptosis — the wrong side effect entirely for the people who buy this.
- Eyelash growth returns to pre-treatment level on stopping. The benefit is temporary and two of the harms are not.
- The 5 ml bottle ships with 140 single-use applicators and the dose is one per eye per night, so the supply claim can be checked against the manufacturer's own component count. Nothing else here allows that.

## Products in the register containing it

| No. | Product | Stance | Score | Document |
| --- | --- | --- | --- | --- |
| R-46 | Allergan Latisse | CONDITIONAL | 81/100 | /reviews/latisse-bimatoprost-review |
| R-32 | Alloy Lash & Brow Serum Rx | CONDITIONAL | 69/100 | /reviews/alloy-lash-brow-serum-review |

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## Elsewhere in the register

- [Review register](/reviews)
- [Active monographs](/actives)
- [Brand register](/brands)
- [Evidence register](/evidence)
- [The ledger](/ledger)
- [How we test](/how-we-test)
- [Agent guide](/llms.txt)
- [Sitemap](/sitemap.xml)

_SOURCE-BASED ASSESSMENTS. PUBLISHER PREFERENCES ARE IDENTIFIED SEPARATELY._