# A-15 — Fluocinolone Acetonide

The component that makes triple therapy tolerable, and the component that makes it a course. Every product built on this pattern needs a stop date.

- **Canonical:** https://www.30plusskin.care/actives/fluocinolone-acetonide
- **Site:** 30+/SKIN — Skincare, published as a spec sheet.
- **Issue:** ISSUE NO. 13 / REV. 2026.10
- **Standing terms:** INDEPENDENT · AFFILIATE-FUNDED · NOT MEDICAL ADVICE

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## Datasheet

- **INN / INCI:** Fluocinolone acetonide
- **Family:** Corticosteroid — low potency
- **Molecular weight:** 452.49 g/mol
- **Layer reached:** EPIDERMIS
- **Prescription only:** yes
- **Evidence grade:** A
- **Controlled trials on file:** 2
- **Strength range recorded:** 0.01%–1%
- **Representative reference concentration:** 0.01%
- **Irritation (0–10):** 1
- **Onset:** 8 WK
- **Stability:** STABLE

## Mechanism

The concentration marker is not a recommended dose or a claim that other strengths are untested. Compare the vehicle, indication and trial population.

Low-potency topical corticosteroid. Suppresses the irritation that hydroquinone and tretinoin produce, and contributes independently to depigmentation.

## Measured endpoints

| Endpoint | Effect vs comparator | Window | Record |
| --- | --- | --- | --- |
| Melasma cleared, as part of triple therapy | +23% | 8 WK | REF-03 — Tri-Luma — trial 1, against hydroquinone + tretinoin in the same vehicle (Randomised, active-controlled against all three two-drug combinations in the identical vehicle, n=338, grade A) |

## Layering

- **Do not layer with:** Indefinite facial use, Occlusion over large surface areas, Application without a stated end date
- **Pairs with:** Hydroquinone, Tretinoin

## Notes

- Facial skin under a topical corticosteroid for months develops atrophy, telangiectasia and perioral dermatitis, and systemic absorption can suppress the HPA axis. The approved product carries that warning.
- It is why the approved triple combination is licensed short-term only and instructs discontinuation when control is achieved.
- This register has found the same pattern rebuilt with hydrocortisone 1% and sold on rolling monthly billing with no duration stated anywhere.
- The concentration range here spans the approved 0.01% in Tri-Luma up to the 1% hydrocortisone used in compounded equivalents — different steroids at very different potencies, doing the same job.

## Products in the register containing it

| No. | Product | Stance | Score | Document |
| --- | --- | --- | --- | --- |
| R-35 | Galderma Tri-Luma | RECOMMENDED | 85/100 | /reviews/tri-luma-cream-review |
| R-43 | Nurx Prescription Skincare | CONDITIONAL | 74/100 | /reviews/nurx-prescription-skincare-review |
| R-45 | Skin + Me The Daily Doser | CONDITIONAL | 70/100 | /reviews/skin-and-me-daily-doser-review |

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## Elsewhere in the register

- [Review register](/reviews)
- [Active monographs](/actives)
- [Brand register](/brands)
- [Evidence register](/evidence)
- [The ledger](/ledger)
- [How we test](/how-we-test)
- [Agent guide](/llms.txt)
- [Sitemap](/sitemap.xml)

_SOURCE-BASED ASSESSMENTS. PUBLISHER PREFERENCES ARE IDENTIFIED SEPARATELY._