# A-17 — Sarecycline

The second considered answer to the antibiotic problem in this register: keep the antibacterial activity, narrow the spectrum, and write the twelve-week limit into the label.

- **Canonical:** https://www.30plusskin.care/actives/sarecycline
- **Site:** 30+/SKIN — Skincare, published as a spec sheet.
- **Issue:** ISSUE NO. 13 / REV. 2026.10
- **Standing terms:** INDEPENDENT · AFFILIATE-FUNDED · NOT MEDICAL ADVICE

---

## Datasheet

- **INN / INCI:** Sarecycline hydrochloride
- **Family:** Tetracycline — narrow spectrum
- **Molecular weight:** 487.5 g/mol
- **Layer reached:** DERMIS
- **Prescription only:** yes
- **Evidence grade:** A
- **Controlled trials on file:** 1
- **Strength range recorded:** 60%–150%
- **Representative reference concentration:** 100%
- **Irritation (0–10):** 2
- **Onset:** 12 WK
- **Stability:** STABLE

## Mechanism

The concentration marker is not a recommended dose or a claim that other strengths are untested. Compare the vehicle, indication and trial population.

A tetracycline-class antibacterial designed with reduced activity against enteric Gram-negative organisms — the part of the spectrum responsible for the collateral damage broad-spectrum tetracyclines cause. Dosed once daily by body weight.

## Measured endpoints

| Endpoint | Effect vs comparator | Window | Record |
| --- | --- | --- | --- |
| IGA success, inflammatory acne | +11.4% | 12 WK | REF-28 — Seysara — study 1 (NCT02320149), inflammatory acne (Multicentre randomised, placebo-controlled; 51% of subjects adults, 15% Black or African American, n=968, grade A) |

## Layering

- **Do not layer with:** Pregnancy and breastfeeding, Children under eight, Any use beyond twelve weeks without a reason
- **Pairs with:** A topical retinoid, Benzoyl peroxide

## Notes

- The limitations of use state that efficacy beyond twelve weeks and safety beyond twelve months have not been established, that it has not been evaluated in the treatment of infections, and that it should be used only as indicated to limit resistance.
- Weight-banded dosing across three tablet strengths, so the dose matches the patient rather than the convention.
- Never compared with doxycycline or minocycline in a trial. The spectrum advantage is a mechanism-level argument, priced as though it were an established outcome.
- Its trial population was 51% adults and 15% Black or African American — better representation than most programmes in this register.

## Products in the register containing it

| No. | Product | Stance | Score | Document |
| --- | --- | --- | --- | --- |
| R-53 | Almirall Seysara | CONDITIONAL | 74/100 | /reviews/seysara-sarecycline-review |

---

## PROMOTIONAL SPOTLIGHT: Explore CoreAge Rx skincare

More options for your skin. A patient community to connect with along the way.

**Five skincare options to explore** — Browse CoreAge Rx's prescription skincare range for concerns including fine lines, dark spots, blemishes and more.

**Connect with other patients** — Explore the CoreAge Rx patient community for shared experiences, conversations and support beyond your daily routine.

[CHECK OUT COREAGE RX SKINCARE](https://try.coreagerx.com/skincare?utm_source=30plusskin.care&utm_medium=affiliate&utm_campaign=skincare_reviews&utm_content=reading_footer)

[EXPLORE THE PATIENT COMMUNITY](https://community.coreagerx.com/)

[Read our CoreAge Rx reviews](/reviews/coreage-rx-skincare-review)

Prescription options require a clinician's assessment. Compounded medications are not FDA-approved. Community discussions do not replace medical advice.

[Product range](https://help.coreagerx.com/medication/coreage-rx-prescription-skincare) · [Community information](https://www.coreagerx.com/contact-us/)

[About promotional placements](/disclosure)

---

## Elsewhere in the register

- [Review register](/reviews)
- [Active monographs](/actives)
- [Brand register](/brands)
- [Evidence register](/evidence)
- [The ledger](/ledger)
- [How we test](/how-we-test)
- [Agent guide](/llms.txt)
- [Sitemap](/sitemap.xml)

_SOURCE-BASED ASSESSMENTS. PUBLISHER PREFERENCES ARE IDENTIFIED SEPARATELY._