# LEO Pharma

One product, and it was the first registration programme in this register enrolled in the population this site is written for — mean age 50.6, range 19 to 92. It is also the cheapest prescription we have assessed.

- **Canonical:** https://www.30plusskin.care/brands/leo-pharma
- **Site:** 30+/SKIN — Skincare, published as a spec sheet.
- **Issue:** ISSUE NO. 13 / REV. 2026.10
- **Standing terms:** INDEPENDENT · AFFILIATE-FUNDED · NOT MEDICAL ADVICE

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## The operation

- **Category:** MANUFACTURED PRESCRIPTION DERMATOLOGY · FDA APPROVED
- **Model:** New Drug Application, manufactured product, retail pharmacy dispensing on a prescriber's script.
- **Products assessed:** 1
- **Mean score:** 81/100
- **Mean disclosure score:** 88/100
- **Pricing:** See each offer and billing period in the product records
- **Brand site:** https://www.leo-pharma.us
- **TRADING NAME:** LEO PHARMA INC.
- **MODEL:** NDA → MANUFACTURE → RETAIL PHARMACY
- **RANGE ASSESSED:** 1 PRODUCT
- **REGULATORY STATUS:** FDA APPROVED
- **TRIAL MEAN AGE:** 50.6 YEARS — THE HIGHEST IN THIS REGISTER
- **FORMULA DISCLOSURE:** FULL — CONCENTRATION, FILL WEIGHT AND EXCIPIENTS

## Verdict

One product assessed. Finacea Foam is azelaic acid 15% in a hydrophilic foam for the papules and pustules of rosacea, and its distinguishing feature in this register is demographic rather than pharmacological: 1,362 subjects aged 19 to 92, mean age 50.6, 73.4% female. Every other registration programme here was run in acne populations with a mean age around twenty.

The efficacy is solid and modestly reported. Investigator global assessment success reached 32.1% and 43.4% against 23.4% and 32.5% on vehicle — gaps of roughly nine and eleven points, with high vehicle responses that the label makes no attempt to minimise. Inflammatory lesions fell by about thirteen from a mean baseline of 21.3.

The vehicle arms are worth as much as the drug arms. Trial subjects were instructed to avoid their own flushing triggers and to stop using soaps, astringents, tinctures and abrasives. A meaningful share of what the vehicle group achieved was trigger avoidance and irritant removal — which is real treatment that costs nothing and that no product page will sell you.

Three warnings are stated specifically and one of them matters. Azelaic acid inhibits tyrosinase, which is why it works on pigment and why hypopigmentation has been reported; the label instructs monitoring in patients with dark complexions and concedes the drug has not been well studied in them. The propellant is flammable. And azelaic acid irritates the eyes. All three are the kind of practical warning a compounded equivalent has no mechanism to deliver.

## What the reviewed offering tells us

### 01 — The only trial population that matches the readership

Mean age 50.6, range 19 to 92. Against acne programmes with mean ages around twenty and 42% to 45% of subjects under eighteen. Almost everything a fifty-year-old is prescribed for their skin was trialled on people half their age, and the extrapolation is so routine nobody names it.

### 02 — The vehicle arm is part of the finding

23.4% and 32.5% of subjects succeeded on foam base plus instructions. The instructions were trigger avoidance and stopping irritants. That is a substantial share of the total benefit, available free, and it is the single most actionable thing on the label.

### 03 — The pigment warning names who it falls on

Hypopigmentation has been reported; azelaic acid has not been well studied in patients with dark complexion; monitor those patients for early signs. The mechanism that treats pigmentation is the mechanism that can remove it where you did not intend, and the label says so rather than leaving it to be discovered.

### 04 — Fifteen per cent is where the evidence lives

This register has found azelaic acid compounded at 17%, 10%, 6% and 4%. The approved rosacea strength is 15% and the approved acne strength is 20%, and both come from trial programmes. Every other figure is an assumption about a dose-response curve nobody has drawn.

### 05 — The cheapest prescription in the register

From around $36 with a discount card against an average retail near $261, with generic azelaic acid 15% widely available and the fill weight published. It is not the most effective rosacea treatment here, but it is the best value by a wide margin.

## Credit where it is due

- A trial population with a mean age of 50.6 and a range of 19 to 92.
- 1,362 subjects across two vehicle-controlled 12-week trials.
- Full IGA scale definitions published, so 'success' is checkable.
- Both trials reported, including the weaker one.
- Complete exclusion criteria published, including ocular, phymatous and plaque-type rosacea.
- The trigger and irritant avoidance instructions given to subjects are published, so the vehicle arm can be understood.
- Hypopigmentation disclosed with a specific instruction to monitor darker complexions.
- Eye irritation and propellant flammability both stated plainly.
- Concentration, fill weight and excipients all published.

## Disclosure matrix

| Product | CONC. ON PAGE | CONC. FINDABLE | CONTRA-INDICATIONS | SIZE | SIDE EFFECTS |
| --- | --- | --- | --- | --- | --- |
| LEO Pharma Finacea Foam | yes | yes | yes | yes | yes |

## Reviews

| No. | Product | Stance | Score | Price | Document |
| --- | --- | --- | --- | --- | --- |
| R-42 | Finacea Foam — Azelaic acid 15% foam | RECOMMENDED | 81/100 | $36 | /reviews/finacea-foam-azelaic-acid-review |

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## Elsewhere in the register

- [Review register](/reviews)
- [Active monographs](/actives)
- [Brand register](/brands)
- [Evidence register](/evidence)
- [The ledger](/ledger)
- [How we test](/how-we-test)
- [Agent guide](/llms.txt)
- [Sitemap](/sitemap.xml)

_SOURCE-BASED ASSESSMENTS. PUBLISHER PREFERENCES ARE IDENTIFIED SEPARATELY._