Hyaluronic Acid
Sodium Hyaluronate (multi-weight)
ALSO — HA
Does nothing structural. Does a great deal optically, within the hour.
WHERE WE SIT IN THE PUBLISHED RANGE0.1% ——— 2%
1%
We compound toward the middle of the published range, not the top of it. Past the point where the dose–response curve flattens, the extra percent buys irritation and nothing else.
IDENTITY & RATINGSB
INCISodium Hyaluronate (multi-weight)
FAMILYHumectant / GAG
MOL. WEIGHT8 kDa / 300 kDa / 1.6 MDa
HOUSE CONC.1% w/w
pH WINDOW4 – 7
ACTS ATSTRATUM CORNEUM
DEPTH0 – 40 µm
ONSETIMMEDIATE
STABILITYSTABLE
TRIALS ON FILE2
IRRITATION INDEX0 / 10
▸ STRATUM CORNEUMEPIDERMISDERMIS
The shaded band is the depth this molecule is understood to reach. Anything below it is out of scope, whatever the label says.
01
Mechanism
EVIDENCE GRADE B
Binds up to a thousand times its weight in water. Three molecular weights: high forms an occlusive film, mid holds the mid-corneum, low reaches the granular layer.
HOUSE NOTES
- In dry air, a humectant with nothing sealing it will pull water out of you, not into you. Always followed by an occlusive step.
02
Layering
CONFLICTS & PAIRINGS
DO NOT LAYER
No known conflicts. This one goes next to anything in the formulary, in any order, on any night.
PAIRS WITH
03
Compounded into
3 FORMULAS