Evidence
register
Every percentage printed anywhere in this catalogue carries a record number. This is the register those numbers resolve to: design, blinding, sample size, duration, endpoint and effect size — with no step in between.
How to read a record
RANDOMISED & CONTROLLED
Randomised or split-face, vehicle- or active-controlled, blinded to at least the investigator. The only design that isolates the molecule from the vehicle, the routine and the season.
CONTROLLED, LIMITED
Controlled but unblinded, small, or ex vivo. Directionally useful. Not enough on its own to justify a claim on a bottle.
MECHANISTIC ONLY
In vitro or open-label. Tells you a pathway exists. Tells you nothing about what happens on a face.
This is a specimen catalogue built as a design demonstration. Every record below is an illustrative placeholder authored for it — the designs and figures are plausible in shape but describe no real trial, and deliberately name no author, institution or journal. Do not cite them.
The register
- REF-01A
Periorbital wrinkle depth
Randomised, vehicle-controlled
DOUBLE-BLINDN = 11212 WEEKSEFFECT SIZE-31%SAMPLE SIZE112 - REF-02A
Dermal echogenicity
Split-face, vehicle-controlled
INVESTIGATOR-BLINDN = 6424 WEEKSEFFECT SIZE+18%SAMPLE SIZE64 - REF-03B
Transepidermal water loss
Open-label cohort
UNBLINDEDN = 488 WEEKSEFFECT SIZE-27%SAMPLE SIZE48 - REF-04A
Melanin index (MASI)
Randomised, active-controlled
DOUBLE-BLINDN = 9616 WEEKSEFFECT SIZE-24%SAMPLE SIZE96 - REF-05A
Inflammatory lesion count
Split-face, vehicle-controlled
INVESTIGATOR-BLINDN = 7212 WEEKSEFFECT SIZE-41%SAMPLE SIZE72CITED BY - REF-06A
Corneometry (hydration)
Randomised, vehicle-controlled
DOUBLE-BLINDN = 12012 WEEKSEFFECT SIZE+39%SAMPLE SIZE120 - REF-07B
Procollagen I expression
Ex vivo skin explant
N/AN = 246 WEEKSEFFECT SIZE+46%SAMPLE SIZE24 - REF-08A
Erythema index
Randomised, vehicle-controlled
DOUBLE-BLINDN = 8812 WEEKSEFFECT SIZE-22%SAMPLE SIZE88 - REF-09C
Barrier recovery rate
Open-label cohort
UNBLINDEDN = 364 WEEKSEFFECT SIZE+34%SAMPLE SIZE36 - REF-10A
Global photodamage score
Randomised, active-controlled
DOUBLE-BLINDN = 14424 WEEKSEFFECT SIZE-29%SAMPLE SIZE144 - REF-11B
Pore visibility count
Split-face, vehicle-controlled
INVESTIGATOR-BLINDN = 528 WEEKSEFFECT SIZE-19%SAMPLE SIZE52 - REF-12C
Tyrosinase inhibition
In vitro enzymatic assay
N/AN = 12NOT APPLICABLEEFFECT SIZE-63%SAMPLE SIZE12 - REF-13A
Skin roughness (Ra)
Randomised, vehicle-controlled
DOUBLE-BLINDN = 10412 WEEKSEFFECT SIZE-26%SAMPLE SIZE104 - REF-14B
Minimal erythema dose
Controlled UV challenge
INVESTIGATOR-BLINDN = 401 WEEKSEFFECT SIZE+58%SAMPLE SIZE40