Panthenol
Panthenol
ALSO — PROVITAMIN B5
The quiet one. Its whole job is making the other actives survivable.
WHERE WE SIT IN THE PUBLISHED RANGE1% ——— 5%
3%
We compound toward the middle of the published range, not the top of it. Past the point where the dose–response curve flattens, the extra percent buys irritation and nothing else.
IDENTITY & RATINGSB
INCIPanthenol
FAMILYHumectant / repair
MOL. WEIGHT205.25 g/mol
HOUSE CONC.3% w/w
pH WINDOW4 – 7
ACTS ATSTRATUM CORNEUM
DEPTH0 – 30 µm
ONSET1 WK
STABILITYSTABLE
TRIALS ON FILE1
IRRITATION INDEX0 / 10
▸ STRATUM CORNEUMEPIDERMISDERMIS
The shaded band is the depth this molecule is understood to reach. Anything below it is out of scope, whatever the label says.
01
Mechanism
EVIDENCE GRADE B
Converts to pantothenic acid in the skin — a coenzyme A precursor feeding lipid synthesis. Also directly humectant and demonstrably anti-inflammatory.
HOUSE NOTES
- Present in six of seven formulas. It is not a headline and it is not optional.
02
Layering
CONFLICTS & PAIRINGS
DO NOT LAYER
No known conflicts. This one goes next to anything in the formulary, in any order, on any night.
PAIRS WITH
03
Compounded into
4 FORMULAS