Tranexamic Acid
Tranexamic Acid
ALSO — TXA
The pigment active that works on the vascular component — the one that survives sun exposure.
WHERE WE SIT IN THE PUBLISHED RANGE2% ——— 5%
3%
We compound toward the middle of the published range, not the top of it. Past the point where the dose–response curve flattens, the extra percent buys irritation and nothing else.
IDENTITY & RATINGSB
INCITranexamic Acid
FAMILYAntifibrinolytic
MOL. WEIGHT157.21 g/mol
HOUSE CONC.3% w/w
pH WINDOW5 – 7
ACTS ATEPIDERMIS
DEPTH20 – 160 µm
ONSET8–12 WK
STABILITYSTABLE
TRIALS ON FILE2
IRRITATION INDEX1 / 10
STRATUM CORNEUM▸ EPIDERMISDERMIS
The shaded band is the depth this molecule is understood to reach. Anything below it is out of scope, whatever the label says.
01
Mechanism
EVIDENCE GRADE B
Interrupts the plasminogen–keratinocyte pathway that drives UV-triggered melanogenesis. Acts upstream of tyrosinase rather than on it.
HOUSE NOTES
- Stacked with A-05 and A-03 it addresses three separate pigment pathways at once. That is the entire logic of the 05 treatment.
02
Layering
CONFLICTS & PAIRINGS
DO NOT LAYER
No known conflicts. This one goes next to anything in the formulary, in any order, on any night.
PAIRS WITH
03
Compounded into
1 FORMULAS