NO. 05
PACKAGINGALUMINIUM TUBE
FILL30 ML
DOSES≈ 85
COST / DOSE£0.68
PRICE£58
SPECIMEN CATALOGUE — NO ORDER WILL BE PLACED
TREATMENT / AM/PM
AZELAIC 10%
Redness, pigment and lesions, one vector each.
ACTIVE LOAD18.0%
WORKING pH4.6 ± 0.2
VISCOSITY4,800 cP
FINISHMatte
FORMULATION
BASESuspension in silicone-free emollient
TEXTUREGrainy on contact, dissolves in 5 s
STABILITY12 MONTHS FROM OPENING
PEAK IRRITATION2 / 10
SCHEDULE
PHASEAM/PM
STEP ORDER03
FREQUENCYDAILY
DOSEPEA-SIZED
01
Composition
% W/W AT COMPOUNDING
Azelaic Acid
Treats redness, post-inflammatory pigment and breakouts at once. Almost nothing else does all three.
ACTS AT EPIDERMISONSET 6–10 WKIRRITATION 2/10CONC.10%56% OF ACTIVE LOADTranexamic Acid
The pigment active that works on the vascular component — the one that survives sun exposure.
ACTS AT EPIDERMISONSET 8–12 WKIRRITATION 1/10CONC.3%17% OF ACTIVE LOADNiacinamide
The generalist. Barrier, tone, oil and pore visibility all move a little. Nothing moves a lot.
ACTS AT EPIDERMISONSET 4–8 WKIRRITATION 1/10CONC.5%28% OF ACTIVE LOAD
FULL INCI, DESCENDING
- 01Aqua
- 02Azelaic Acid
- 03Niacinamide
- 04Tranexamic Acid
- 05Squalane
- 06Glycerin
- 07Panthenol
- 08Xanthan Gum
EXCLUDED BY POLICY
- FRAGRANCE
- DENAT. ALCOHOL
- ESSENTIAL OILS
- COLOURANT
02
Measured endpoints
MEDIAN CHANGE VS. VEHICLE
SUPPORTING RECORDS
Randomised, active-controlled
N=96 · 16 WK · DOUBLE-BLIND
Split-face, vehicle-controlled
N=72 · 12 WK · INVESTIGATOR-BLIND
Randomised, vehicle-controlled
N=88 · 12 WK · DOUBLE-BLIND
In vitro enzymatic assay
N=12 · N/A · N/A