Bimatoprost
Bimatoprost
The largest, least ambiguous cosmetic result in this register — alongside two harms that do not reverse when you stop.
The marker is a representative concentration from the cited records. The bar includes approved and compounded preparations recorded here. It is not a recommended dose, a minimum effective strength or a claim that other concentrations are untested. Evidence depends on the vehicle, indication and trial population.
The shaded band is the depth this molecule is understood to reach. Anything below it is out of scope, whatever the label says.
Mechanism
Extends the anagen growth phase of the eyelash follicle and increases the number of hairs in it. The same prostaglandin activity acts on melanocytes and on orbital adipose tissue, and cannot be dialled out.
HOUSE NOTES
- Increased brown iris pigmentation may occur and the label says it is likely to be permanent.
- Postmarketing reports include periorbital fat atrophy producing a deepened eyelid sulcus and eyelid ptosis — the wrong side effect entirely for the people who buy this.
- Eyelash growth returns to pre-treatment level on stopping. The benefit is temporary and two of the harms are not.
- The 5 ml bottle ships with 140 single-use applicators and the dose is one per eye per night, so the supply claim can be checked against the manufacturer's own component count. Nothing else here allows that.
Layering
- Prostaglandin analogues for intraocular pressure
- Active uveitis
- Risk factors for macular edema
- Nothing — apply alone to the upper lid margin