Against the actives arms race
Ten percent niacinamide is not twice as good as five. The dose–response curve flattens and the complaint rate does not.
FILE
ENTRYL-03
FILED2026-05-19
LENGTH5 MIN
SUBJECTSDOSE-RESPONSE, FORMULATION
Concentration is the easiest number to put on a bottle and the least informative one on it. It says nothing about pH, nothing about vehicle, nothing about whether the molecule reaches the layer it acts on.
A 20% vitamin C at pH 4.2 is a 0% vitamin C with a marketing budget.
We compound to the middle of the published effective range, not the top of it. Where the curve flattens, the extra percent buys irritation and nothing else — and an irritated barrier is a barrier that absorbs unpredictably, which corrupts every other step.
FIGURES
NIACINAMIDE, HOUSE5%
NIACINAMIDE, PUBLISHED RANGE2–10%
ASCORBIC ACID, HOUSE15% @ pH 3.0
RETINAL, HOUSE0.10%
POSITIONMID-RANGE, NOT MAXIMUM
DOSE-RESPONSEFORMULATION