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← LEDGERENTRY L-03FILED 2026-05-195 MIN

Against the actives arms race

Ten percent niacinamide is not twice as good as five. The dose–response curve flattens and the complaint rate does not.

FILE
ENTRYL-03
FILED2026-05-19
LENGTH5 MIN
SUBJECTSDOSE-RESPONSE, FORMULATION

Concentration is the easiest number to put on a bottle and the least informative one on it. It says nothing about pH, nothing about vehicle, nothing about whether the molecule reaches the layer it acts on.

A 20% vitamin C at pH 4.2 is a 0% vitamin C with a marketing budget.

We compound to the middle of the published effective range, not the top of it. Where the curve flattens, the extra percent buys irritation and nothing else — and an irritated barrier is a barrier that absorbs unpredictably, which corrupts every other step.

FIGURES
NIACINAMIDE, HOUSE5%
NIACINAMIDE, PUBLISHED RANGE2–10%
ASCORBIC ACID, HOUSE15% @ pH 3.0
RETINAL, HOUSE0.10%
POSITIONMID-RANGE, NOT MAXIMUM
FIGURES IN THIS ENTRY ARE DRAWN FROM THE REVIEW REGISTER. NOT MEDICAL ADVICE.
DOSE-RESPONSEFORMULATION
NEXT — L-02

Retinisation is not a result

THE DRAW · NO. 01

Win a year of
prescription skincare

One reader gets a 12 months CoreAge Rx derm plan — the compounded, physician-reviewed subscription we take apart in the register. Worth $780. Leave an address and you are entered.

PRIZE
12 MONTHS OF COREAGE RX
VALUE
$780 — $64.99/MO × 12
ENTRY
ONE EMAIL ADDRESS

VALUE IS THE PUBLISHED $64.99/MONTH SUBSCRIPTION PRICE OVER TWELVE MONTHS, AS RECORDED IN R-10. NO PURCHASE NECESSARY. WE REVIEW COREAGE RX — WE DO NOT SELL IT.

DEPTH 000%
THE DRAW · ONE READER

Win a year of
prescription skincare

One reader gets a 12 months CoreAge Rx derm subscription — compounded, physician-reviewed, delivered. The plan we score in the register.

VALUE$780
TERM12 MONTHS$64.99/MO × 12

VALUE IS THE PUBLISHED $64.99/MONTH SUBSCRIPTION PRICE OVER TWELVE MONTHS, AS RECORDED IN R-10. NO PURCHASE NECESSARY. WE REVIEW COREAGE RX — WE DO NOT SELL IT.